FKBP4 and Alzheimer disease: We then used the radial-arm water maze (RAWM) task (Fig. 4a) to evaluated if FKBP52 overexpression in the hippocampus affected spatial learning and memory in rTg4510 and wild-type mice, as this is known to be altered in the rTg4510 model and is commonly disrupted in AD patients (reviewed in32).