Additionally, our data reported that depleted HOTAIR or DNMT1 reduced the proliferation, colony formation, invasion, migration, as well as increased apoptosis rate of CML cells, while low expression of HOTAIR or decreased DNMT1 reduced the volume and weight of tumor in mice injected with CML cells. Here, DNMT1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.