Our previous study of epigenetic regulation in Alzheimer’s disease and T cell exhaustion showed that histone acetylation is involved in long non-coding RNA NEAT1- and splicing factor SRSF2-mediated expression of endocytosis-related genes and tumor-related immune checkpoint genes, respectively, by recruiting signal transducer and activator of transcription 3 to these gene promoters11,12. This evidence concerns the gene STAT3 and early-onset autosomal dominant Alzheimer disease.