A study of the roles of BCOR mutations in oculo-facio-cardio-dental syndrome, a rare genetic disorder characterized by canine teeth with extremely long roots, and eye, craniofacial, and cardiac abnormalities, revealed that the BCOR mutation enhanced the osteogenic capacity of MSCs by promoting the expression of AP-2α, a key factor that mediates the osteo/dentinogenic differentiation of MSCs by interfering with the interaction of FBXL10, also known as Jumonji C histone demethylase 1B with the AP-2α promoter, thereby increasing H3K4me3 and H3K36me2 levels at this promoter62. This evidence concerns the gene BCOR and hereditary disease.