CD4 and viral infectious disease: Up-regulated genes were mainly involved in inflammatory responses and responses to virus infection, with innate immunity components (type-I IFN-mediated response, NK cell activation, TLRs, RLRs, NF-κB and Jak-STAT signaling pathways), adaptive immunity components (TH1, TH2, CD4+ T-cells) and functions related to chemokine signaling.