To further evaluate the prognostic importance of ECD mRNA expression, we performed multivariate analyses with a model incorporating clinical features (age, tumor size, tumor grade, ER status, PR status, and HER2 status) in both TCGA and METABRIC cohorts, and ECD overexpression was shown to be an independent significant predictor of poor outcome (see Table S2B). The gene discussed is ESR1; the disease is neoplasm.