The accumulation of phosphorylated At8 and At180 tau protein has been previously linked with Lyn activity in the context of AD [18]: Remarkably, neither γ-synuclein nor tau phospho-epitopes At8 and 180 accumulated in isolated basal ganglia from Vps13a−/− Lyn−/− mice (Additional file 1: Fig. S7B-C). This evidence concerns the gene MAPT and Alzheimer disease.