NDE1 and lissencephaly spectrum disorders: Of note, a recent study on NudE Neurodevelopment Protein 1 (NDE1) gene-whose protein is involved in dynein function and whose mutations are associated with human microhydrancephaly and lissencephaly-showed that a human-linked alternate terminal exon could be responsible for the appearance of gyri in mammals, including in pigs and bovine [13].