We next examined the effect of methyl (4, 6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3, 4-b] pyridine-3-yl) pyrimidin-5-yl) (methyl) carbamate; Riociguat, BAY 63-2521, a stimulator of sGC, which is a drug used to treat pulmonary arterial hypertension in SSc patients. The gene discussed is SGCB; the disease is pulmonary arterial hypertension.