Further, to infer the putative therapeutic targets for Alzheimer’s disease, we used the mean value of the class probability of “positive” from the 100 binary classifier to prioritize the 6,307 genes (see Table 1 and Supplementary Table 1 for details); i.e., the unknown targets with a higher mean value of “positive” for the class probability (e.g., DLG4 in Table 1 and Supplementary Table 1) are more likely potential novel drug targets. Here, DLG4 is linked to early-onset autosomal dominant Alzheimer disease.