BRAF and cancer: The 7q34 amplification was also significantly associated with CTCF binding site mutations in oesophageal cancer (interaction P = 0.034) (Additional file 1: Figure S7C); however, no matching RNA-seq data was available to confirm the transcriptional upregulation of BRAF. Thus, our analysis associates BRAF amplifications and point mutations to localised mutagenesis in multiple cancer types.