The 7q34 amplification was also significantly associated with CTCF binding site mutations in oesophageal cancer (interaction P = 0.034) (Additional file 1: Figure S7C); however, no matching RNA-seq data was available to confirm the transcriptional upregulation of BRAF. Thus, our analysis associates BRAF amplifications and point mutations to localised mutagenesis in multiple cancer types. Here, CTCF is linked to cancer.