The mean serum WBC count, CRP level, and ESR in the culture-negative PJI group were significantly lower than those in the culture-positive PJI group (WBC: 8218 cells/μL versus 6185 cells/μL, p = 0.011; CRP: 5.0 mg/dL versus 2.5 mg/dL, p = 0.032; and ESR: 60 mm/h versus 47 mm/h, p = 0.036; respectively, Fig. 2). The gene discussed is CRP; the disease is juvenile polyposis syndrome.