ESR1 and hepatocellular carcinoma: Meanwhile, the three NRs including pregnane X receptor (NR1I2) (HR = 0.81, 95% CI: 0.68-0.96, p = 0.013), estrogen receptor α (ESR1) (HR = 0.77, 95% CI: 0.63-0.94, p = 0.012), and androgen receptor (AR) (HR = 0.82, 95% CI: 0.69-0.99, p = 0.038) were also significantly related to the overall survival in HCC samples, but these three NRs were protective genes that can be favorable for prognosis (Fig. 2a).