The main coactivators nuclear receptor coactivator (NCoA) 1 to 3, NCoA-6, peroxisome proliferator-activated receptor coactivator 1α (PGC1-α), p300, cAMP response element binding protein (CREB) binding protein (CREBBP) and methyl-CpG binding endonuclease (MED1), and corepressors nuclear receptor co-repressor (N-CoR) 1 and 2, nuclear receptor-interacting protein (NRIP1) and metastasis-associated protein 1 (MTA1) of nuclear receptors have been identified to contribute to the treatment of colorectal cancer [12]. This evidence concerns the gene CREBBP and colorectal cancer.