Meanwhile, the three NRs including pregnane X receptor (NR1I2) (HR = 0.81, 95% CI: 0.68-0.96, p = 0.013), estrogen receptor α (ESR1) (HR = 0.77, 95% CI: 0.63-0.94, p = 0.012), and androgen receptor (AR) (HR = 0.82, 95% CI: 0.69-0.99, p = 0.038) were also significantly related to the overall survival in HCC samples, but these three NRs were protective genes that can be favorable for prognosis (Fig. 2a). The gene discussed is NR1I2; the disease is hepatocellular carcinoma.