REN and substance dependence: The top five most prescribed therapeutic groups by pharmacist prescribers were contraceptives-hormonal with 159,013 dispensings (17.9%), followed by vaccinations (128,332 (14.4%)), treatments for substance dependence (113,378 (12.7%)), lipid-modifying agents (38,199, (4.3%)), and agents affecting the renin-angiotensin system (37,353 (4.2%)).