Indeed, several researches has reported that ALDOA and PGK1 also mediated in OSCC and head and neck squamous cells carcinoma (HNSCC) [30, 32].Ahluwalia also reported that HIF-1 under hypoxic conditions regulates the expression of vascular endothelial growth factor A (VEGFA) at the transcriptional level [33]. This evidence concerns the gene PGK1 and head and neck squamous cell carcinoma.