This study analyzed gene expression of inflammatory mediators (IL-1B, IL-6, IL-8, IL-10, INF-γ and TNF-α,) and two metalloproteases associated with esophageal mucosa damage as reported in previous studies in patients with 3 different endoscopic phenotypes of the disease (BE, EE and NERD). This evidence concerns the gene IL1B and ethylmalonic encephalopathy.