However, Vinther-Jensen and colleagues reported an age, CAG and Bonferroni-corrected correlation between CSF NfL and TMS in manifest HD, and an association between NfL and cognitive impairment in their PM + HD cohort, suggesting that NfL levels in CSF might be more reflective of neurodegeneration than plasma NfL [4]. This evidence concerns the gene NEFL and Cognitive impairment.