CD274 and non-small cell lung carcinoma: Nonetheless, the clinical utility of TMB as a biomarker together with PD-L1 evaluation remains an enigma further complicated by the variety of measuring assays and algorithms.15, 16, 17, 18, 19 Interestingly, no significant association between PD-L1 expression and TMB has been observed,20 even when comparing the results obtained from the same NSCLC tissue samples.21