However, not much is still known about the role of ORMDLs, particularly ORMDL3 that has been implicated in asthma pathogenesis (10, 11, 12, 13), in regulating sphingolipid metabolism and levels of bioactive sphingolipid metabolites, and which specific sphingolipid levels are altered (14). This evidence concerns the gene ORMDL3 and asthma.