Even more importantly, the observed reduction in classical HLA-DRA, HLA-DRB1, HLA-DPA1 and HLA-DPB1 transcription as well as the decline in monocyte HLA-DR surface expression persisted in all patients with postoperative sepsis despite a recovery of CIITA transcription levels during the study period. This evidence concerns the gene HLA-DPA1 and Sepsis.