As an important finding, these interactions were confirmed for pairs of CTCF-sites and promoter regions of genes, which also displayed sepsis-induced alterations in our study (CM1 and HLA-DRA, CM2 and HLA-DRB1, CM9 and HLA-DPA1 and CM9 and HLA-DB1). Here, HLA-DRB1 is linked to Sepsis.