In COVID-19, it has been shown previously that HMGB1 plasma levels are elevated in severe disease,23,24 and are predictive of a fatal outcome, with an AUCs of 0.694.24 Our results are in accordance with these previous studies but show a substantial better accuracy for predicting a fatal outcome with an AUCs of 0.865. The gene discussed is HMGB1; the disease is COVID-19.