ALB and Sepsis: Morbid obesity was not independently associated with most perioperative complications measured by the ACS-NSQIP and was associated only with increases in progressive renal insufficiency, superficial SSI, and sepsis among the 21 perioperative variables measured. Low serum albumin was associated with increased mortality and multiple additional major perioperative complications after TKA. Low serum albumin, more so than morbid obesity, was associated with major perioperative complications.