More importantly, cg11024682 in SREBF1 and cg06500161 in the ABCG1 gene could mediate 45.3% and 19.5% of the BMI‐NSCLC association, respectively, suggesting the biological role of DNA methylation on the association between BMI and reduced lung cancer risk in the Chinese populations. The gene discussed is ABCG1; the disease is non-small cell lung carcinoma.