The results showed that the TNF‐α (880.74 ± 206.23 vs 116.86 ± 28.82 pg./mg, P < 0.0001), IL‐6 (541.01 ± 118.38 vs 101.01 ± 28.25 pg./mg, P < 0.0001), and IL‐1β (812.66 ± 178.75 vs 164.53 ± 49.00 pg./mg, P < 0.0001) levels were significantly raised in the DM‐OA group compared to the Ctrl group. The gene discussed is IL1B; the disease is diabetes mellitus.