Despite the current dilemma to effectively treat MI/R injury, a number of studies investigating multiple animal MI/R injury models have suggested that some bioactive peptides could display protective activities against MI/R injury, such as vasonatrin,28 circulating ghrelin,29 intermedin30 and recombinant human brain natriuretic peptide.31 The gene discussed is GHRL; the disease is myocardial infarction.