In addition, even in the primary melanoma tissue, the percentage of samples from more severe tumours (stages III and IV) negative for mGPDH staining was higher than that among samples from less severe tumours (stages I and II) (Figure S1B), and similar mGPDH expression profiles were found in primary melanoma tissues with lymph node metastasis (Figure S1C). The gene discussed is GPD2; the disease is neoplasm.