GPD2 and melanoma: With the melanoma tissue array, we found that most primary melanoma tissues showed more obvious IHC staining for mGPDH than the metastatic tissues, as shown in Figure 1B. Specifically, the percentage of primary melanoma patients with a high IHC score (++, +++) was 33.66%, which was more than that for patients with metastatic melanoma (18.58%) (Figure 1C).