HE and Masson staining results exhibited that the proliferation of glomerular mesangial cells, hyperplasia of glomeruli and interstitium and fibrosis were alleviated by lnc‐ISG20 knockdown (Figure 3C) and collagen deposition (blue) was significantly reduced after lnc‐ISG20 knockdown (Figure 3D), indicating that lnc‐ISG20 knockdown delayed DN‐related renal fibrosis. The gene discussed is ISG20; the disease is liver dysplastic nodule.