AKT1 and renal fibrosis: Existent reports suggest that AKT can be modulated by several upstream regulators, like tamoxifen, Aloe‐Emodin, miRNAs, and thus regulate fibrosis in kidney, liver and heart etc.58, 59, 60Additionally, AKT phosphorylation has also been previously demonstrated to be implicated in renal dysfunction, such as renal tubular cell apoptosis, renal fibrosis.23, 61, 62