MKI67 and neoplasm: To identify the patients at higher risk of LDR, a retrospective stratification was carried out according to CTS5 and other parameters commonly used in the clinical practice: tumor size (T1, T2, T3 or higher), nodal involvement (pN0, pN1, pN2-3), stage of the disease (Stages I, II, III), tumor grade (low, intermediate, high), Ki67 (low [< 20%], high [> 20%]), and progesterone receptor status (negative [< 1%], positive [> 1%]).