CD8A and neoplasm: In addition to the abscopal effect, Gu andco-workers report that their therapy elicits immune memory and canprotect previously cured mice from relapse after rechallenging themwith fresh tumor cells.361 These data corroboratean earlier report by Wang and co-workers, which explored alginatehydrogel mediated codelivery of aPD-1 and the anti-inflammatory drugcelecoxib in the B16F10 and 4T1 models.366 The combination of these two drugs proved to be synergistic, drivingincreased CD4+ and CD8+ effector T cell infiltration into tumors whiledepleting MDSCs and regulatory T cells.