TP53 and heart disorder: In 114 newly diagnosed MM patients with TP53 abnormalities, we found that patient age and stage of the disease were the strongest predicting factors for patient PFS and OS, with older age and later stages indicative of worse prognosis, consistent with reports from other groups [24,25]. Patients’ lifestyles (smoking, etc.)and preexisting conditions (heart diseases, etc.)did not have strong effects on patient survival.