Here, we provide an intensive retrospective analysis of a large cohort of newly diagnosed MM patients to identify the clinical significance of TP53 and common cytogenetic abnormalities. We compare TP53 loss and amplification together with common genes dysregulated in MM patients, including chromosome 1q21 amplification, translocation of 4p16.3 (fibroblast growth factor receptor 3, FGFR3), and translocation of 16q23 (MAF) to chromosome 14q32. This evidence concerns the gene TP53 and Miyoshi myopathy.