Loss of function in the tumour suppressor gene SNF5 (also known as SMARCB1, INI1, and BAF47), a subunit of the SNF/SWI complex, results in unopposed EZH2 activity and increased H3K27me3 levels which drive tumour growth in the absence of EZH2 gain of function mutations (Fig. 1) [7••]. Here, SMARCB1 is linked to neoplasm.