SORT1 and coronary artery calcification: Apart from being strongly associated with plasma LDL cholesterol levels, the SORT1 locus is also associated with CAD (3, 5, 6, 8, 14–17) and a wide range of different vascular subphenotypes including early-onset myocardial infarction (1, 2), coronary stenosis (5, 8), coronary artery calcification (6), abdominal aorta aneurysm (4), and aortic valve calcification (18).