SORT1 and coronary artery disorder: The aim of this study was to evaluate sortilin as a biomarker for CAD in a well-characterized cohort by (1) identifying genetic variants associated with variation in plasma sortilin level, (2) analyzing the effect of common clinical risk factors for CAD on sortilin levels, (3) investigating the association of sortilin with coronary calcium score and CAD severity, and (4) testing if circulating sortilin could improve risk stratification of patients with symptoms of CAD.