In conclusion, we have identified two cis-pQTLs for plasma sortilin at 1p13.3, where one of the pQTLs is a strong risk variant for CAD, with the risk allele for CAD driving lower levels of soluble sortilin in plasma, which is the same direction as the SORT1 transcript in the human liver. This evidence concerns the gene SORT1 and coronary artery disorder.