PERK has been shown to support tumor growth, metastasis, autophagy, and radiation resistance and was therefore proposed as a future therapy target to overcome therapy failure (Bobrovnikova-Marjon et al., 2010; Avivar-Valderas et al., 2011; Rouschop et al., 2013; Liu et al., 2015; Feng et al., 2017; Salaroglio et al., 2017; Zhang et al., 2018). This evidence concerns the gene EIF2AK3 and neoplasm.