Another report showed that inhibition of the PERK–eIF2α-GRP94 signaling pathway silenced the epidermal growth factor receptor (EGFR) and then increased the radiosensitivity of both radiosensitive and radioresistant oropharyngeal squamous cell carcinoma (OSCC) cells (Zhang et al., 2018). The gene discussed is EIF2AK3; the disease is oropharynx squamous cell carcinoma.