We then investigated the potential functions of PERK in certain cancers and found that PERK was significantly enriched in the immune-related signaling pathways in BRCA, HNSC, and THCA, including B-cell differentiation, T-cell differentiation, T-cell activation, etc. This finding is consistent with previous studies showing that PERK has an essential function in the differentiation of naive B cells into plasma cells (Gass et al., 2008; Ma et al., 2010; Zhu et al., 2019). The gene discussed is EIF2AK3; the disease is cancer.