Previous studies have proven that PERK has the function of supporting tumor growth, metastasis, autophagy, and radiation resistance (Bobrovnikova-Marjon et al., 2010; Avivar-Valderas et al., 2011; Rouschop et al., 2013; Liu et al., 2015; Salaroglio et al., 2017). The gene discussed is EIF2AK3; the disease is neoplasm.