The linear regression analysis of metabolites and lipid species to the SYNTAX scores (atherosclerotic burden), cTnI (myocardial necrosis), and hs-CRP (inflammatory state) was conducted by adjusting for traditional risk factors, including age, sex, hypertension, diabetes mellitus, smoking, LDLC, HDLC, and TG. The gene discussed is TNNI3; the disease is Hypertension.