Recently, it has been shown that neoplastic transformation by silencing GSTP1 tumor suppressor gene function might be mediated by activation of c-myc (Boldrini et al., 2019), whereas the significant protective effect was shown after GSTP1 overexpression in PC in vitro and in vivo (Wang et al., 2017). Here, GSTP1 is linked to pachyonychia congenita.