When GSTO1 rs4925 and GSTO2 rs156697 polymorphisms were analyzed in combination, carriers of at least one variant GSTO1*A and GSTO2*G alleles had a 1.8-fold higher risk of developing PC compared to referent genotype combination (95%CI: 1.07–2.96, p = 0.026) (Table 2). The gene discussed is GSTO1; the disease is pachyonychia congenita.