SERPINE1 and Sepsis: In effect, thrombin-antithrombin complex, PAI-1 and D-dimer have been already proposed as potential biomarkers for the identification of the clinical phenotypes of sepsis, being significantly associated with the δ phenotype, which is characterized by a distinctive pattern of organ dysfunction and higher mortality (2); thereafter, such biomarkers might be useful in identifying those patients most likely to benefit from anti-inflammatory, anti-coagulant or immunomodulatory strategies (17).