PDPN and neoplasm: In this process, several interactions are responsible for the firm cohesion of platelets to tumor cells, such as the binding between (i) C-type lectin-like receptor 2 (Clec-2) on platelets with podoplanin on tumor cells, (ii) P-selectin on activated platelets, and Sialyl-Lewisx-conjugates on tumor cells, and (iii) the integrins αIIbβ3 on platelets and αVβ3 on tumor cells, which both bind to a fibrin bridge.