FN1 and neoplasm: Accordingly, synergistic activation of TGFβ-Smad and NF-κB pathways downregulate epithelial markers such as claudin1 and E-cadherin, but lead to upregulation of mesenchymal transcription factors such as snail and twist, and marker proteins including vimentin and fibronectin in tumor cells (Labelle et al., 2011; Mittal, 2018).