NLRP3 and diabetes mellitus: Similar to the above, recent evidence suggests that hyperglycemia promotes oxidative stress and inflammation in the development of memory and cognitive impairment caused by diabetes (Miguel Roman-Pintos et al., 2016), while the inhibition of HG-induced NLRP3 inflammasome has protective effects on memory and cognitive impairment (Ye et al., 2018a; Zhai et al., 2018).