To explore whether LECT2 acts as a tumor suppressor in pancreatic cancer, PDAC cell lines BXPC-3 and ASPC-1 were transfected with lentiviral vectors encoding human LECT2 inserts, whereas MiaPaca-2 and Panc-1 cells were transfected with shRNAs targeting LECT2 based on the endogenous expression of LECT2 (Supplementary Figure 2). Here, LECT2 is linked to pancreatic neoplasm.