Although recent studies on MAP3K13, the human homolog of Wnd, have revealed its tumor promoting roles in head and neck squamous cell carcinoma (HNSCC) and hepatocellular carcinoma (HCC) patients (Edwards et al., 2017; Zhang et al., 2020), the mechanism by which Wnd/MAP3K13 regulates tissue growth remains underexplored. This evidence concerns the gene MAP3K13 and hepatocellular carcinoma.