Finally, another study suggested that impaired fasting-induced steatosis in Atg5-Li KO mice is not related to changes in de novo lipid biogenesis or β-oxidation levels, but rather to increased activation of NRF2 (nuclear factor erythroid 2–related factor 2), since double-knockout animals for ATG5 and NRF2 had restored phenotypes (Li et al., 2018). Here, ATG5 is linked to steatosis.