TFEB and metabolic dysfunction-associated steatotic liver disease: Even though AMPK activity can modulate lysosome function by regulating TFEB activation, V-ATPase activity, and calcium transport in different physiological or pathological contexts (McGuire and Forgac, 2018; Bonam et al., 2019; Fernandez-Mosquera et al., 2019; Deus et al., 2020), to the best of our knowledge the participation of similar mechanisms in NAFLD models has not yet been further explored.