Also, experiments that overexpressed ATG7 in adult ob/ob mice (Yang et al., 2010), that overexpressed ATG14 in mice fed a HFD (Xiong et al., 2012), or that overexpressed TFEB in the livers of adult C57BL/6 mice before (Settembre et al., 2013) and even after 12 weeks of HFD (Zhang et al., 2018) all found decreased hepatic TG content, corroborating the idea that reactivation of autophagy in NAFLD can be a strategy to improve steatosis and other associated metabolic dysfunctions. Here, ATG7 is linked to metabolic dysfunction-associated steatotic liver disease.