TBK1 and metabolic dysfunction-associated steatohepatitis: Interestingly, p62 aggregation induced by lipotoxicity is dependent on its phosphorylation by TBK1 (TANK Binding kinase 1) at the same residue, while inhibition of this kinase prevented the formation of ubiquitin-p62 aggregates in mouse NASH models (Cho et al., 2018).