Mutations in the ORAI1 gene have been reported in a range of diseases (Figure 3 and Tables 1, 2), including: tubular aggregate myopathy (TAM), SCID, congenital miosis, ectodermal dysplasia anhidrosis (EDA), and Stormorken-like syndrome (Böhm et al., 2017; Garibaldi et al., 2017). Here, ORAI1 is linked to severe combined immunodeficiency.