Altogether, our study emphasizes that UII and its receptor UT are more expressed in GBMs than in low-grade gliomas, specifically in vascular and hypoxia mesenchymal areas, and play a major role in gliomagenesis via, at least in part, angiogenesis, promoting MMP-2/-9 and αV integrin expression within the tumor bulk. This evidence concerns the gene UTS2 and central nervous system cancer.