Despite a report suggesting that UT relays activation of HIF-1α through NOX2 in endothelial cells controlling tubulogenesis in vitro (Diebold et al., 2012), we did not observe UII-evoked induction of HIF-1/2 in normo- or hypoxic conditions in GBM or EC in vitro. The gene discussed is HIF1A; the disease is glioblastoma.