Shimokawa et al. (2017) found that Lgr5+ colon CSCs had the potential for self-renewal and differentiation, driving the growth of colon cancer, and tumorigenesis can be regressed once the CSCs are lost. Pancreatic cancer is a malignant tumor with a high fatality rate, partly due to its persistent metastasis, in which pancreatic CSCs play crucial roles. Furthermore, the CD133+ and CXCR4+ pancreatic CSCs control the metastasis of pancreatic cancer, and their ablation can lead to the loss of the pancreatic cancer metastatic phenotype (Hermann et al., 2007). Here, LGR5 is linked to familial pancreatic carcinoma.