In T-cell acute lymphoblastic leukemia (T-ALL), the Notch-regulated cheRNA LUNAR1 binds to the enhancer of IGF1R, activates the promoter of IGF1R in cis, maintains a high level of mRNA expression, and promotes the growth of T-ALL (Trimarchi et al., 2014). The gene discussed is IGF1R; the disease is acute lymphoblastic leukemia.