PROM1 and familial pancreatic carcinoma: Shimokawa et al. (2017) found that Lgr5+ colon CSCs had the potential for self-renewal and differentiation, driving the growth of colon cancer, and tumorigenesis can be regressed once the CSCs are lost. Pancreatic cancer is a malignant tumor with a high fatality rate, partly due to its persistent metastasis, in which pancreatic CSCs play crucial roles. Furthermore, the CD133+ and CXCR4+ pancreatic CSCs control the metastasis of pancreatic cancer, and their ablation can lead to the loss of the pancreatic cancer metastatic phenotype (Hermann et al., 2007).