The cheRNA LUCAT1 promotes the proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) by increasing the stability of DNA methyltransferase 1 (DNMT1) and increases the methylation level of tumor suppressor factors, leading to the proliferation and metastasis of ESCC (Yoon et al., 2018). This evidence concerns the gene DNMT1 and esophageal squamous cell carcinoma.