Deletion of RAGE attenuates leukocyte recruitment and protects against atherosclerosis by reducing oxidative stress and decreasing the expression of proinflammatory markers, including NF-κB p65, VCAM-1, and MCP-1, in diabetic ApoE(–/–) mice (Soro-Paavonen et al., 2008). This evidence concerns the gene APOE and atherosclerosis.