BMP7 and obesity due to melanocortin 4 receptor deficiency: BMP7 controls the development and maintenance of multiple physiological processes in the human body, and its aberrant expression has found to be associated with a variety of pathologic conditions (i.e., incomplete fracture healing, the development of bone metastases in cancers, renal fibrosis, obesity, and OA) (Boon et al., 2011).