Tumor immune infiltration is also closely related to patient treatment and prognosis, and the evidence in the literature indicates that increased immune infiltration of M2-like macrophages, CD8 T, NK, mast cells, B cells, and type 2 T helper cells in the EW microenvironment are significantly associated with poor prognosis in EW patients (Kastrinakis et al., 2000; Guzik and Barañska, 2013; Hernandez et al., 2018). Here, CD8A is linked to neoplasm.