RETREG1 and hereditary sensory and autonomic neuropathy: RETREG1 (reticulophagy regulator 1; a.k.a. FAM134B) on 5p15.1 is a cis-Golgi transmembrane protein, and mutations in this gene lead to the production of an impaired gene product, which is unable to act as an autophagy receptor and leads to hereditary sensory and autonomic neuropathy in humans (HSAN IIB; OMIM 613135).