PPARA and Zinc deficiency: It was reported that MI-induced zinc deficiency aggravates pro-inflammatory and impairs anti-inflammatory responses in vascular endothelial cells though activation of NF-κB and inhibition of PPAR pathways (Connell et al., 1997; Li and Karin, 1999; Chung et al., 2000; Delerive et al., 2000; Hihi et al., 2002; Griendling and FitzGerald, 2003).