AGT and Sepsis: In these studies, the authors were able to demonstrate that patients who were treated with angiotensin II had improved 28-day survival and earlier discontinuation of RRT (77), and that these advantages were best seen in patients who had higher serum renin levels prior to angiotensin II administration, suggestive of sepsis-induced angiotensin converting enzyme deficiency (and thus angiotensin II deficiency) in the setting of endothelial injury (66).