Results from this work informed a second study in which the protein products of five of the aforementioned 21 genes–elastase 2 (ELA2), fibroblast growth factor 13, matrix metalloproteinase 8 (MMP8), olfactomedin 4 (OFM4), and proteinase 3 (PRTN3) – were incorporated into a new CART-derived model to predict the presence of SA-AKI at day 3 of septic shock (10). The gene discussed is PRTN3; the disease is acute kidney injury.