FREM1 and Pfeiffer syndrome type 1: In our study, a genetic diagnosis has been identified for 15 out of 28 patients as follows: Hypo-phosphasia (two patients), Apert syndrome (three patients), Crouzon syndrome (two patients), Seather-Chotzen, (three patients), TCF12 related CS (one patient), Pfeiffer syndrome Type 1 (one patient) FREM1-related trigonocephaly type 2 (two patient) and AD CR type 3 (one patient).